Effect of beinaglutide, a thrice-daily GLP-1 receptor agonist, on body weight and metabolic parameters: A systematic review and meta-analysis

Jun 9, 2025World journal of diabetes

Beinaglutide taken three times daily and its effects on body weight and metabolism: A combined analysis of studies

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Abstract

Beinaglutide 0.1-0.2 mg thrice daily resulted in an average body weight reduction of 3.25 kg over 12-24 weeks compared to the control group.

Beinaglutide demonstrated a statistically significant reduction in body weight and percent weight loss compared to the control group.
It was associated with a higher likelihood of achieving at least 5% (odds ratio 4.61) and 10% (odds ratio 5.34) weight loss.
The treatment also resulted in a significant decrease in body mass index (BMI) and waist circumference (WC).
No significant differences were observed in blood pressure, glycemic parameters, insulin resistance, hepatic transaminases, or lipid profile between the groups.
Beinaglutide had higher rates of treatment discontinuation and specific adverse events such as nausea and vomiting compared to the control group.
Safety profiles were consistent with other drugs in the glucagon-like polypeptide-1 receptor agonist class.

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BACKGROUND: Beinaglutide, a short-acting glucagon-like polypeptide-1 receptor agonist, has shown variable efficacy in weight reduction and metabolic control in randomized controlled trials (RCTs).

AIM: To summarize the therapeutic effects of beinaglutide in patients with overweight/obesity with/without type 2 diabetes.

METHODS: RCTs involving patients receiving beinaglutide in the intervention arm and placebo or active comparator in the control arm were searched through multiple electronic databases. The change from baseline in body weight was the primary outcome; secondary outcomes included changes in body mass index (BMI), waist circumference (WC), blood pressure, glycemic parameters, lipids, and adverse events (AEs). RevMan web was used to conduct meta-analysis using random-effects models. Outcomes were presented as mean differences (MDs), odds ratios (ORs), or risk ratios (RRs) with 95% confidence intervals (95%CIs).

RESULTS: Six RCTs (= 800) with mostly some concerns about the risk of bias were included. Over 12-24 weeks, beinaglutide 0.1-0.2 mg thrice daily was superior to the control group in reducing total (MD = -3.25 kg, 95%CI: -4.52 to -1.98,= 84%,< 0.00001) and percent (MD = -4.13%, 95%CI: -4.87 to -3.39,= 54%,< 0.00001) body weight reduction. Beinaglutide also outperformed the control group in achieving weight loss by 5% (OR 4.61) and 10% (OR = 5.34). The superiority of beinaglutidethe control group was also found in reducing BMI (MD = -1.22 kg/m, 95%CI: -1.67 to -0.77) and WC (MD = -2.47 cm, 95%CI: -3.74 to -1.19]). Beinaglutide and the control group had comparable impacts on blood pressure, glycemic parameters, insulin resistance, hepatic transaminases, and lipid profile. Beinaglutide posed higher risks of treatment discontinuation due to AEs (RR = 3.15), nausea (RR = 4.51), vomiting (RR = 8.19), palpitation (RR = 3.95), headache (RR = 2.87), and dizziness (RR = 6.07) than the control. However, the two groups had identical risks of total and serious AEs, diarrhea, fatigue, and hypoglycemia. n I P I P vs2 2 2

CONCLUSION: Short-term data from RCTs suggested that beinaglutide causes modest benefits in reducing body weight, BMI, and WC, with no significant difference in glycemic and other metabolic endpoints compared to the control arm. Safety data were consistent with those of the other drugs in the glucagon-like polypeptide-1 receptor agonist class. Larger RCTs are warranted to prove the longer-term metabolic benefits of beinaglutide.

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Effect of beinaglutide, a thrice-daily GLP-1 receptor agonist, on body weight and metabolic parameters: A systematic review and meta-analysis

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