Benzofuran as a promising scaffold for the synthesis of novel antimicrobial agents

The review highlights the antimicrobial potential of benzofuran compounds, which may exhibit equal or greater efficacy compared to established antibiotics.

• Benzofuran scaffolds demonstrate significant antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as fungal microorganisms.
• The electronic nature of substituents on benzofurans influences their antimicrobial effectiveness, as indicated by structure-activity relationship studies.
• Recent studies from 2019-2022 report the success of various natural and synthetic benzofuran-based molecules in antimicrobial applications.
• Many benzofurans show promise as antimicrobial agents, potentially offering alternatives to traditional antibiotics targeting Gram-positive infections.

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