An update on benzofuran inhibitors: a patent review

Thirty-four benzofuran-based drugs are currently available on the market.

• Benzofuran compounds are associated with a wide range of biological activities, including anticancer, antitubercular, antidiabetic, anti-Alzheimer, and anti-inflammatory effects.
• Recent developments highlight their roles as inhibitors against diseases, viruses, fungi, microbes, and enzymes.
• The review covers findings from 2014 to 2019, emphasizing various activities such as antimicrobial, anti-inflammatory, antitumor, and antioxidant effects.
• Certain functional groups, such as -OH, -OMe, sulfonamide, or halogen, may enhance the therapeutic activities of benzofuran derivatives compared to reference drugs.
• Potential pro-drugs derived from benzofurans are outlined, indicating further avenues for pharmaceutical development.

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