Bifrontal electroconvulsive therapy changed regional homogeneity and functional connectivity of left angular gyrus in major depressive disorder

Oct 10, 2020Psychiatry research

Electroconvulsive therapy alters local activity and connections in the left thinking and language area in major depression

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Abstract

ReHo values in the left angular gyrus (LAG) significantly increased in MDD patients after ECT.

Bifrontal ECT was administered to MDD patients and evaluated using resting-state functional MRI.
Functional connectivity of the LAG with several brain regions strengthened after ECT.
Increased LAG connectivity was observed with areas including the inferior temporal gyrus and middle frontal gyrus.
Delayed recall scores in a verbal learning test were associated with LAG connectivity to specific brain regions.
The findings suggest the LAG may play an important role in the mechanism of ECT for MDD.

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Electroconvulsive therapy (ECT) is a rapid and effective treatment for MDD. However, the mechanism of ECT for MDD has not been clarified. In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) to explore the mechanism of ECT. Two groups of subjects were recruited: healthy controls (HCs) and MDD patients who received bifrontal ECT. MDD patients and HCs underwent rs-fMRI scans and clinical assessments (Hamilton Depression Rating Scale, Rey-Auditory Verbal Learning Test (RAVLT), and the verbal fluency test). Regional homogeneity (ReHo) and functional connectivity were evaluated for the analysis of rs-fMRI data. The results showed that ReHo values in the left angular gyrus (LAG) significantly increased in MDD patients after ECT, and the functional connectivity of the LAG with bilateral inferior temporal gyrus, bilateral middle frontal gyrus, left superior frontal gyrus, left middle temporal gyrus, left precuneus, left posterior cingulate gyrus, and right angular gyrus was found to be strengthened after ECT. The scores of delayed recall trial in the RAVLT of MDD patients were related to the functional connectivity of the LAG with the left inferior temporal gyrus and the left posterior cingulate gyrus. It indicated LAG palyed an important role in the mechanism of ECT in MDD.

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Bifrontal electroconvulsive therapy changed regional homogeneity and functional connectivity of left angular gyrus in major depressive disorder

Abstract

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