Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health

Bile acids are linked to various metabolic functions and health outcomes.

• Bile acids function as signaling molecules that interact with cellular receptors like FXR and TGR5.
• These interactions influence lipid and cholesterol metabolism, energy metabolism, immune system function, and intestinal electrolyte balance.
• The gut microbiota can alter bile acid signaling properties through enzymatic activities, impacting host health.
• Changes in gut microbiota related to bile acid metabolism are associated with conditions such as obesity, inflammatory bowel disease, and colorectal cancer.
• The gut-microbiota-liver axis presents a potential target for new dietary and pharmaceutical interventions.

AI simplified