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Bile Acid Signaling in Metabolic Disease and Drug Therapy
Bile acid signals in metabolism-related diseases and drug treatments
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Abstract
Bile acids are the end products of cholesterol breakdown and play a crucial role in daily cholesterol turnover.
- Hepatic bile acid synthesis is a significant component of cholesterol turnover in humans.
- Bile acids facilitate the secretion of lipids and other metabolites through bile flow.
- In the intestine, bile acids are vital for absorbing dietary fats and fat-soluble vitamins.
- Bile acids function as signaling molecules, influencing lipid, glucose, and energy metabolism.
- Circadian rhythms affect bile acid synthesis, which is linked to metabolic homeostasis.
- Alterations in gut microbiota and circadian rhythms may contribute to various liver and metabolic diseases.
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