Bile acid levels linked to initial and changing amyloid and tau buildup in Alzheimer's patients

DCA- and LCA-family bile acids were linked to amyloid and tau pathology in Alzheimer's disease cohorts.

This observational cohort analysis used Chinese Preclinical Alzheimer's Disease Study (n = 1397) and Alzheimer's Disease Neuroimaging Initiative (n = 1275) datasets to relate bile acid levels to baseline and longitudinal AD biomarkers.

The associations and imaging transcriptomic analyses do not prove that bile acids cause AD pathology or improve prediction clinically.