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Mechanism of Bile‐Processed Coptidis Rhizoma in the Treatment of Type 2 Diabetes Mellitus in Rats Based on Dissolution Kinetics and Untargeted Metabolomics
How Bile-Processed Coptidis Rhizoma Helps Treat Type 2 Diabetes in Rats Based on Drug Release and Metabolic Changes
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Abstract
Bile-processed Coptidis Rhizoma (BPCR) significantly reduced fasting blood glucose levels in T2DM rats.
- BPCR demonstrated stronger diffusion and dissolution of alkaloids compared to Coptidis Rhizoma (CR).
- Treatment with BPCR led to significant reductions in both fasting blood glucose and serum insulin levels in T2DM rats.
- BPCR improved glucose and lipid metabolism while also mitigating liver damage in the treated rats.
- A total of 27 endogenous differential biomarkers were significantly regulated by BPCR based on serum metabolomics analysis.
- The effects of BPCR may be related to pathways involving glycerophospholipid metabolism, linoleic acid metabolism, steroid biosynthesis, and arachidonic acid metabolism.
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