Biochanin A improves hepatic steatosis and insulin resistance by regulating the hepatic lipid and glucose metabolic pathways in diet‐induced obese mice

Biochanin A (BA) improved hepatic steatosis and insulin resistance in high-fat diet-fed mice over 12 weeks.

• BA prevented obesity-induced fatty liver and insulin resistance in mice fed a high-fat diet.
• Administration of BA activated PPAR-α and increased its expression and regulatory proteins in the liver.
• BA enhanced the recovery of metabolites linked to fat synthesis and breakdown in the livers of obese mice.
• Levels of metabolites related to glucose production were reduced by BA, along with decreased expression of key enzymes.
• These findings suggest that BA could help manage metabolic disorders associated with diet-induced obesity.

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