Biochemical processes behind brain changes caused by psychedelics

Psychedelics may promote structural and functional neuroplasticity in the prefrontal cortex (PFC), potentially leading to lasting behavioral changes.

• The atrophy of neurons in the PFC is a common feature of stress-related neuropsychiatric disorders such as depression and PTSD.
• Psychedelics could serve as effective catalysts for the growth of neurons in the PFC.
• Restoration of synaptic connectivity in the PFC may result from psychedelic-induced neuroplasticity.
• The hallucinogenic effects of psychedelics appear unrelated to their capacity to promote neuroplastic changes.
• Understanding the molecular mechanisms of psychedelic-induced neuroplasticity is essential for developing alternative treatments for neuropsychiatric conditions.

Simplified