Engineering methods to create blood vessels in organ-like tissues

Bioengineering strategies are rapidly advancing to enable efficient vascularization of organoids.

• Organoids are three-dimensional structures derived from stem cells that can model organ development and diseases.
• The lack of an integrated vascular network limits the translational potential of organoids.
• Various methods for vascularization include co-culturing with vascular cell types and using organoid-on-a-chip technology.
• 3D bioprinting is also being explored to create organoids with perfusable vasculature.
• The integration of stem cell biology, biomaterials, and fabrication technologies may lead to more complex organoid models.

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