A cell membrane-covered DNA nanoplatform for reshaping cartilage and joint lining interaction in osteoarthritis

CM@THC, a biomimetic nanoplatform, effectively restored redox balance and mitochondrial function in chondrocytes.

• Mitochondrial dysfunction and chondrocyte senescence are linked to cartilage degeneration in osteoarthritis.
• The engineered nanoplatform combines hesperidin with tetrahedral framework nucleic acids and chondrocyte membranes for enhanced targeting.
• CM@THC improved cellular uptake and retention within the joint environment.
• Restoration of redox homeostasis and mitophagy was achieved in inflammatory chondrocytes, reducing cellular aging effects.
• The treatment limited the activation of fibroblast-like synoviocytes, which are involved in joint pathology.

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