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Joint association and interaction of birth weight and lifestyle with hypertension: A cohort study in UK Biobank
How Birth Weight and Lifestyle Together Relate to High Blood Pressure
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Abstract
6.59% of participants developed incident hypertension during a median follow-up of 8.6 years.
- Lower birth weight is associated with a higher risk of developing hypertension, with a hazard ratio of 1.12 per kg decrease in birth weight.
- A healthier lifestyle is linked to a reduced risk of hypertension, with a hazard ratio of 0.76 for each increment in .
- The protective effect of a healthy lifestyle against hypertension is stronger in individuals with lower birth weights (<2500 g and 2500-2999 g).
- An additive interaction was observed between birth weight and healthy lifestyle score, indicating a relative excess risk due to this interaction of 0.04.
- The findings highlight the significance of maintaining a healthy lifestyle, particularly for those at higher risk due to lower birth weight.
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Key numbers
3.23Ă
Increase in Hypertension Risk
Risk of hypertension in lowest birth weight and high-risk lifestyle score group.
53.6%
Proportion of Preventable Hypertension
Estimated proportion of hypertension incidents preventable in low birth weight and high group.