Life (Basel, Switzerland)

Changes in the Blood-Brain Barrier and Small Blood Vessel Problems in Long COVID

Abstract

Endothelial dysfunction, microthrombosis, and disruption of the blood-brain barrier are central mechanisms identified in COVID-19 related cerebrovascular damage.

  • COVID-19 is associated with respiratory issues and chronic cerebrovascular damage.
  • Endothelial biomarkers and neuroimaging findings suggest significant involvement of endothelial dysfunction.
  • Microthrombosis may contribute to both acute and chronic ischemic and hemorrhagic events in the brain.
  • Disruption of the blood-brain barrier could play a role in the neurological complications observed post-infection.
  • Understanding these mechanisms is essential for addressing population health impacts related to COVID-19.

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