Blood coagulation in immunothrombosis—At the frontline of intravascular immunity

Fibrin is the structural basis of immunothrombotic clots involved in the innate immune response.

• Hemostasis prevents blood loss after vessel injury, while thrombosis is typically seen as pathological.
• Recent findings indicate that thrombosis may also function as a physiological response called immunothrombosis.
• Immunothrombosis is initiated by the innate immune system to control local infections.
• The formation of fibrin involves coagulation factors, platelets, and leukocytes working together.
• Aberrant activation of fibrin formation pathways is associated with various thrombotic diseases.

AI simplified