Thrombosis as an intravascular effector of innate immunity

Thrombosis is the most frequent cause of mortality worldwide.

• Thrombosis is closely linked to haemostasis, the process that stops bleeding.
• Recent findings suggest thrombosis may play a significant role in immune defense.
• The term immunothrombosis has been introduced to describe thrombi formation as an innate immune response.
• Immunothrombosis occurs primarily in microvessels and involves immune cells and specific molecules related to thrombosis.
• This process creates an intravascular scaffold that helps identify, contain, and destroy pathogens.
• Uncontrolled immunothrombosis is associated with various pathological conditions related to thrombosis.

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