Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors

All members of the REV-ERB and ROR families are crucial components of the molecular circadian clock.

• REV-ERB proteins repress the transcription of the clock gene Bmal1.
• ROR proteins activate the transcription of Bmal1.
• The transcription of Bmal1 results from competition between REV-ERBs and RORs at their response elements.
• Reverb genes show similar expression patterns in the thymus, skeletal muscle, and kidney.
• Ror genes exhibit distinct expression patterns in different tissues.
• The findings provide insights into functional differences between circadian clocks in various parts of the body.

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