Research Progress of BMAL1 in Heart Failure

BMAL1 deficiency is associated with myocardial metabolic dysfunction and impaired cardiac function in heart failure.

• BMAL1 is a core circadian clock gene involved in regulating circadian rhythms and cardiac remodeling.
• Deficiency of BMAL1 can lead to cardiomyocyte hypertrophy, activation of inflammatory responses, and fibrosis.
• These pathological changes contribute to the onset and progression of heart failure.
• The review details mechanisms by which BMAL1 influences metabolism, inflammation, and fibrosis in the context of heart failure.
• Future prospects include the potential for correcting circadian rhythm disruptions and exploring chronotherapy as treatment options.

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