We can’t show the full text here under this license.
Abstract
Female mice hearts expressed significantly more rhythmically expressed genes (REGs) than male hearts.
- The cardiac circadian transcriptome is highly sex-specific, despite common expression of core clock genes in both sexes.
- Temporal distribution of REGs differs between male and female mouse hearts.
- Knocking out the core factor Bmal1 in adult heart cells significantly reduced observed sex differences in circadian transcriptomes.
- Loss of Bmal1 led to about an 8-fold reduction in the number of differentially expressed genes between male and female hearts.
- Sex-specific changes were noted in several cardiac-specific transcription factors, including Gata4, Nkx2-5, and Tbx5.
Simplified