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Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms
Daily liver gene activity changes controlled by the body clock and eating patterns
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Abstract
High-amplitude mRNA expression rhythms in wild-type mouse livers are primarily driven by the .
- Genetic deletion of core clock genes reduced rhythmic feeding patterns during ad libitum feeding.
- Night-restricted feeding restored rhythmic patterns attenuated by core clock gene ablation.
- Rhythmic feeding contributed to gene expression rhythms, but with lower amplitudes compared to the circadian clock.
- Differences in gene expression levels observed between wild-type and knockout mice were associated with .
- In PARbZip knockout mice, mean expression levels of PARbZip target genes were more affected than their rhythmic patterns.
- Identified genes that lost rhythmicity in PARbZip knockouts were found to be indirect targets.
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Key numbers
33%
System-Driven Genes
Percentage of rhythmic genes in wild-type mice that are system-driven.
54%
Loss of Rhythmicity
Percentage of rhythmic transcripts that lost rhythmicity in clock-disrupted mice.
32%
Restoration of Rhythmicity
Percentage of rhythmic genes restored under night-restricted feeding in clock-disrupted mice.