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Rhythmic Food Intake Drives Rhythmic Gene Expression More Potently than the Hepatic Circadian Clock in Mice
Regular Meal Timing Influences Daily Gene Activity in the Liver More Strongly Than the Liver’s Internal Clock in Mice
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Abstract
More than 70% of the cycling mouse liver transcriptome loses rhythmicity under arrhythmic feeding.
- Daily rhythms in gene expression are present in mammalian tissues, influencing tissue-specific processes.
- Core clock genes maintain normal oscillations even when food intake is not rhythmic.
- Rhythmic food intake affects the timing of important signaling and metabolic pathways.
- Systemic signals from food intake play a significant role in regulating liver gene expression rhythms.
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