Regular Meal Timing Influences Daily Gene Activity in the Liver More Strongly Than the Liver’s Internal Clock in Mice

More than 70% of the cycling mouse liver transcriptome loses rhythmicity under arrhythmic feeding.

• Daily rhythms in gene expression are present in mammalian tissues, influencing tissue-specific processes.
• Core clock genes maintain normal oscillations even when food intake is not rhythmic.
• Rhythmic food intake affects the timing of important signaling and metabolic pathways.
• Systemic signals from food intake play a significant role in regulating liver gene expression rhythms.

Simplified