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The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression
The liver’s insulin sensor is needed to set its daily clock and gene rhythms
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Abstract
In the absence of insulin receptors, the rhythmicity of core-clock gene expression is altered in response to day-restricted feeding.
- Insulin secretion is influenced by food intake and plays a significant role in liver circadian rhythms.
- Hepatocyte-restricted deletion of insulin receptors disrupts the normal oscillation of gene expression in the liver.
- Changes in core-clock gene expression correlated with impaired reprogramming of liver gene expression.
- An intact insulin receptor in liver cells is necessary for proper programming of the liver clock and its rhythmic gene expression.
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