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BMAL1-Downregulation Aggravates Porphyromonas Gingivalis -Induced Atherosclerosis by Encouraging Oxidative Stress
Lower BMAL1 Levels May Worsen Gum Bacteria-Linked Artery Disease by Increasing Oxidative Stress
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Abstract
Porphyromonas gingivalis may accelerate atherosclerosis progression by triggering arterial oxidative stress and inflammatory responses in mice.
- Atherosclerotic cardiovascular diseases are linked to chronic inflammation processes.
- Circadian clock disruption is associated with increased atherosclerosis progression.
- Activation of the TLRs-NF-κB signaling pathway by infection may lead to enhanced oxidative stress.
- Downregulation of a specific protein (BMAL1) could release another protein (CLOCK), which further stimulates inflammatory responses.
- Joint administration of melatonin and metronidazole may serve as an effective treatment strategy for atherosclerotic cardiovascular diseases.
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