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Protective effects of tanshinone IIA on Porphyromonas gingivalis-induced atherosclerosis via the downregulation of the NOX2/NOX4-ROS mediation of NF-κB signaling pathway
Tanshinone IIA may protect against artery disease caused by Porphyromonas gingivalis by reducing harmful molecules and inflammation signals
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Abstract
Tanshinone IIA (TSA) at 60 mg/kg/d significantly reduced atherosclerotic lesions in P. gingivalis-infected ApoE-knockout mice.
- TSA treatment led to significant decreases in reactive oxygen species (ROS), 8-OHdG, and oxidized LDL levels in the serum.
- Mice treated with TSA showed reduced mRNA levels of COX-2, LOX-1, NOX2, and NOX4 in the aorta.
- Decreased levels of NOX2, NOX4, and NF-κB were observed in TSA-treated mice, indicating reduced oxidative stress.
- These findings suggest that TSA may mitigate oxidative stress and alleviate atherosclerosis linked to P. gingivalis infection.
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