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Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity
How the body’s clock gene Bmal1 relates to tumor growth and cancer drug response
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Abstract
Knockdown of the Bmal1 gene accelerated tumour growth in mice.
- Down-regulation of Bmal1 gene expression increased cell proliferation in laboratory settings.
- Suppressing Bmal1 expression in colon cancer and fibroblast cells decreased cell death caused by anti-cancer drugs.
- Bmal1 deficiency led to altered levels of several key proteins involved in cell cycle regulation, including increased cdc2 and cyclins.
- Loss of Bmal1 reduced the expression of genes associated with apoptosis and cell cycle control.
- Bmal1 may influence the development of tumours and the effectiveness of anti-cancer treatments.
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