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The brain-joint axis: links between osteoarthritis and neurodegenerative disorders in aging
Connections Between Osteoarthritis and Brain Degeneration in Older Adults
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Abstract
Osteoarthritis (OA) is linked to neurodegenerative disorders through a shared network of inflammation and metabolic stress.
- Chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, and cellular aging are common factors in OA and neurodegenerative diseases.
- The concept of the 'brain-joint axis' describes the communication between the nervous system and joint tissues.
- Proinflammatory cytokines may drive systemic inflammation that impacts both cartilage and neurons.
- OA might be part of a larger neuro-immuno-endocrine network affecting brain health.
- This review proposes that targeting the brain-joint axis could help address both OA and neurodegenerative conditions.
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