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Brain resident microglia in Alzheimer’s disease: foe or friends
Microglia in the brain during Alzheimer's disease: harmful or helpful?
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Abstract
Microglial cells are involved in synaptic pruning and remodeling by producing inflammatory mediators in Alzheimer's disease.
- Microglia act as key monitors of brain health by engaging in processes like phagocytosis and releasing soluble factors.
- In Alzheimer's disease, the conditional transformation between pro-inflammatory and anti-inflammatory microglial states may influence the progression of the disease.
- Accumulation of amyloid-β and tau proteins is associated with increased neuroinflammatory processes mediated by microglia.
- Various microglial phenotypes, including disease-associated microglia and human AD microglia, are linked to the incidence of Alzheimer's disease.
- Microglial-based therapies could potentially address neuroinflammatory responses and help mitigate cognitive deficits in Alzheimer's disease.
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