Effects of bright light and melatonin treatment in a person with a non-24-hour sleep-wake cycle

A patient with non-24 h sleep-wake syndrome achieved appropriate entrainment to a 24 h day through bright light exposure and melatonin treatment.

• Morning bright light exposure and evening melatonin both phase-advanced the patient's sleep-wake cycles.
• These treatments were associated with a phase-advanced melatonin rhythm.
• The patient struggled to maintain morning bright light therapy after discharge.
• Melatonin treatment was found to be better tolerated due to its ease of application.

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