Bright light therapy stabilizes the antidepressant effect of partial sleep deprivation

70% of patients with major depressive disorder experienced a significant reduction in depressive symptoms following partial sleep deprivation.

• Partial sleep deprivation may lead to an acute reduction in depressive symptoms for many patients with major depressive disorder.
• Relapse of depressive symptoms typically occurs after one night of recovery sleep.
• Bright light therapy, initiated the morning after partial sleep deprivation, could prevent relapse in patients who responded to sleep deprivation.
• In responders, bright light therapy significantly prolonged the antidepressant effects of partial sleep deprivation for up to 7 days.
• Patients receiving dim light therapy did not experience sustained improvement and relapsed after recovery sleep.
• Nonresponders to partial sleep deprivation did not show any benefit from light treatment.

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