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Brain signaling through glucagon-like peptide-1 receptors directly controls heat production in brown fat
Updated
Abstract
Intracerebroventricular injection of proglucagon-derived peptides reduces body weight and increases interscapular brown adipose tissue (iBAT) .
- PGDP administration enhances the activity of sympathetic fibers that innervate brown adipose tissue.
- The thermogenic response requires activation of GLP-1 receptors for oxyntomodulin despite its role as a glucagon receptor agonist.
- Increased thermogenesis in wild-type mice is associated with higher expression of genes related to adrenergic signaling.
- GLP-1 receptor signaling is not necessary for normal thermogenic responses to cold exposure in GLP-1 receptor-deficient mice.
- The findings indicate that pharmacological activation of GLP-1 receptors may influence energy balance through enhanced BAT thermogenesis.
Simplified
Key numbers
10.6%
Body Weight Reduction
Average percent change in body weight for WT mice after ICV OXM infusion.
0.08
iBAT Temperature Increase
P-value trend indicating increased iBAT after ICV GCG administration.