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Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus
Using Brown and Beige Fat Tissue as a New Treatment Approach for Obesity and Type 2 Diabetes
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Abstract
Activating (BAT) and inducing the 'browning' of white adipose tissue (WAT) may improve glycolipid metabolism and insulin resistance in obese and type 2 diabetes mellitus (T2DM) patients.
- White adipose tissue primarily stores excess energy as triglycerides, while brown adipose tissue is involved in thermogenesis and temperature regulation.
- White adipocytes can change into , which share characteristics with brown adipocytes, through stimuli like exercise and cold exposure.
- Beige adipocytes can also arise from specific progenitor cells within the tissue, aside from transdifferentiation.
- Activating BAT and promoting WAT browning could enhance the uptake of glycolipids and lower the need for insulin secretion.
- The review highlights the potential role of brown and beige adipose tissues in obesity and T2DM treatment.
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