Unveiling Butyrate as a Parkinson’s Disease Therapy

Oct 15, 2025Neuroscience bulletin

Butyrate as a potential treatment for Parkinson's disease

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Abstract

Butyrate, a short-chain fatty acid, is linked to reduced intestinal permeability and increased systemic inflammation.

  • A decrease in butyrate-producing bacteria is associated with lower butyrate levels.
  • Reduced butyrate levels may contribute to increased intestinal permeability and systemic inflammation.
  • Butyrate has a potential therapeutic role in Parkinson's Disease.
  • The review discusses butyrate's functions and mechanisms in the gut and its impact on the gut-brain axis.
  • Effects of butyrate supplementation are examined in both animal models and human clinical studies.

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