BVES helps keep the colon lining intact in colitis by controlling gut leakiness

Bvesmice demonstrate greater colonic injury and altered immune responses following infection with Citrobacter rodentium.

• At baseline, Bvesmouse colons show increased crypt height, elevated cell proliferation, and decreased cell death.
• Bvesmice exhibit dysregulated tight junctions, leading to functional deficits in intestinal permeability and altered immunity.
• Inoculation with Citrobacter rodentium results in greater bacterial colonization and translocation in Bvesmice.
• Treatment with dextran sodium sulfate (DSS) leads to increased histologic injury in Bvesmice compared to controls.
• Human ulcerative colitis biopsy specimens show reduced levels of BVES mRNA, indicating its potential protective role in colonic health.

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