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BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability
BVES helps keep the colon lining intact in colitis by controlling gut leakiness
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Abstract
Bvesmice demonstrate greater colonic injury and altered immune responses following infection with Citrobacter rodentium.
- At baseline, Bvesmouse colons show increased crypt height, elevated cell proliferation, and decreased cell death.
- Bvesmice exhibit dysregulated tight junctions, leading to functional deficits in intestinal permeability and altered immunity.
- Inoculation with Citrobacter rodentium results in greater bacterial colonization and translocation in Bvesmice.
- Treatment with dextran sodium sulfate (DSS) leads to increased histologic injury in Bvesmice compared to controls.
- Human ulcerative colitis biopsy specimens show reduced levels of BVES mRNA, indicating its potential protective role in colonic health.
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