Levels of C-Reactive Protein in Bipolar and Unipolar Depression

CRP levels were higher in bipolar disorder (BD) patients than in unipolar depression (UD) patients and healthy controls during the acute phase.

• In the acute phase, BD patients exhibited higher CRP levels than UD patients and healthy controls.
• UD patients showed lower CRP levels than healthy controls during the acute phase.
• CRP levels in BD patients during a manic episode were elevated compared to healthy controls.
• During depressive or mixed episodes, CRP levels in BD patients were similar to those of healthy controls.
• CRP levels during acute depressive episodes in BD and UD patients yielded an area under the curve of 0.676, indicating potential diagnostic utility.
• CRP may serve as a marker for acute manic episodes in BD and acute depressive episodes in UD.

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