The effects of calorie-matched high-fat diet consumption on spontaneous physical activity and development of obesity

A high-fat diet (60% calories from fat) reduced spontaneous physical activity in mice within the first 48 hours.

• Spontaneous physical activity decreased significantly on a high-fat diet compared to a control diet over 12 weeks.
• Body weight and adiposity increased in mice on the high-fat diet compared to those on the control diet.
• Inflammatory markers, including TNF-α and IL-6, were elevated in the high-fat diet group.
• Blood glucose levels and plasma insulin were higher in the high-fat diet group, indicating hyperinsulinemia.
• Alterations in the expression of genes related to energy homeostasis were observed in the hypothalamus of high-fat diet-fed mice.

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