Effect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial

Aug 18, 2020European journal of nutrition

Two years of calorie restriction and its effects on liver health markers

AI simplified

Longevity & Aging on OpenScience ↗PubMed ↗DOI ↗

Abstract

After 2 years of calorie restriction, alkaline phosphatase decreased by 7 ± 1 IU/L in healthy individuals without obesity compared to those consuming a normal diet.

Calorie restriction may improve liver health by reducing specific liver enzymes in healthy adults.
Decreases in alkaline phosphatase and gamma-glutamyl transferase were significant in the calorie restriction group.
Bilirubin levels increased in the calorie restriction group, indicating potential metabolic changes.
No significant changes in alanine aminotransferase or aspartate aminotransferase were observed between the groups.
Men in the calorie restriction group showed greater improvements in liver biomarkers compared to women.

AI simplified

PURPOSE: Calorie restriction (CR) is an effective treatment for obesity-related liver and metabolic disease. However, CR studies in individuals without obesity are needed to see if CR could delay disease onset. Liver biomarkers indicate hepatic health and are linked to cardiometabolic disease. Our aim was to examine the effects of a 2-year CR intervention on liver biomarkers in healthy individuals without obesity.

METHODS: The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) study was a 2-year randomized controlled trial. Overall, 218 participants (body mass index: 25.1 ± 1.7 kg/m) were enrolled into a control group (n = 75) that ate ad libitum (AL), or a CR group (n = 143) that aimed to decrease energy intake by 25%. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and bilirubin were measured during the trial. 2

RESULTS: At month 24, relative to the AL group, ALP (- 7 ± 1 IU/L; P < 0.01) and GGT (- 0.11 ± 0.04 log IU/L; P = 0.02) decreased and bilirubin increased (0.21 ± 0.06 log mg/dL; P < 0.01) in the CR group; no between-group differences in ALT (- 1 ± 1 IU/L; P > 0.99) or AST (2 ± 2 IU/L; P = 0.68) were revealed. However, sex-by-treatment-by-time interactions (P < 0.01) were observed, with CR (vs. control) inducing reduced ALT and GGT and increased AST in men only (P ≤ 0.02).

CONCLUSIONS: In metabolically healthy individuals without obesity, 2 years of CR improves several liver biomarkers, with potentially greater improvements in men. These data suggest that sustained CR may improve long-term liver and metabolic disease risk in healthy adults.

TRIAL REGISTRATION: Clinicaltrials.gov (NCT00427193). Registered January 2007.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text (HTML) ↗

Effect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the longevity & aging brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the longevity & aging brief