Cancer Chemotherapy and Heterocyclic Compounds

Jun 8, 2002Current medicinal chemistry

Cancer chemotherapy and related ring-shaped chemical compounds

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Abstract

Heterocyclic organic compounds have shown interesting cytotoxicity profiles in the treatment of neoplastic diseases.

Neoplastic transformation is linked to gene alterations or oncogene activation.
Progress in drug development for malignant diseases has been rapid, particularly since 1940.
Cancer chemotherapy is now recognized as a highly specialized field.
Modifications to antitumor compounds have been made to improve their reactivity profiles.
Classes of heterocycles, including pyrrole, pyrimidine, indole, quinoline, and purine, are among those studied for their cytotoxic effects.

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The search for pharmacological approaches to neoplastic disease has made some impressive gains started after 1940 when the antileukemic activity of nitrogen mustard was discovered during world war II. It is generally accepted that neoplastic transformation is related to genes alteration or oncogene activation, so the progress in the development of the new drugs for treatment of malignant diseases has been rapid, both in revealing pathobiology of the diseases and discovery of new drugs. In addition attempts have been made to define optimal combinations, treatment strategies and patient support measures. Cancer chemotherapy is now of established value and a highly specialized field. Among the modifications to the family of antitumor compounds, heterocyclic organic compounds have been extensively applied by many groups in order to modify the reactivity profile. Pyrrole, pyrimidine, indole, quinoline and purine are few classes of heterocycles which showed interesting cytotoxicity profiles. The updated material related to these modifications has been rationalized and ordered, in order to offer an overview of the argument.

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Cancer Chemotherapy and Heterocyclic Compounds

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