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Carbonate-Bearing Ionizable Lipids for mRNA Delivery to Splenic NK Cells
Ionizable Lipids with Carbonate Groups for Delivering mRNA to Spleen Natural Killer Cells
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Abstract
CAIL-based lipid nanoparticles achieve robust mRNA translation in splenic NK cells, inducing transfection in 21% of these cells.
- A library of 161 carbonate-bearing ionizable lipids was designed to enhance mRNA delivery to NK cells.
- These lipid nanoparticles (LNPs) primarily target the spleen rather than the liver, unlike traditional LNPs.
- Removing cholesterol from CAIL LNPs significantly improves spleen-targeting specificity and efficacy.
- Optimized CAIL LNPs may effectively address the challenges of mRNA delivery to NK cells.
- The findings suggest potential for developing NK cell-based mRNA therapies.
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