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One‐Component Cationic Lipids for Systemic mRNA Delivery to Splenic T Cells
Single-part positively charged lipids for delivering mRNA to spleen T cells throughout the body
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Abstract
One-component ionizable cationic lipids can efficiently deliver mRNA to the spleen and T cells.
- Targeted delivery to specific cell types in the spleen is crucial for mRNA immunotherapy.
- Conventional lipid nanoparticles are limited in their ability to target liver and muscle tissues.
- The newly designed cationic lipids, rich in secondary amines, serve as effective standalone carriers for mRNA.
- In vitro and in vivo tests indicate high efficacy in delivering mRNA to T cell subsets after intravenous administration.
- This approach may enhance the development of non-liver mRNA delivery systems, expanding options for immunotherapy.
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