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Abstract
Post-exertional malaise (PEM) may reflect disrupted coordination across physiological systems in individuals with Long COVID.
- PEM is characterized by symptom exacerbation or emergence of new symptoms after exertion.
- Disruption in physiological coordination may result in altered post-exertional physiological trajectories.
- These trajectories could contribute to multisystem manifestations and potential cardiometabolic issues.
- Longitudinal assessment of physiological responses may help contextualize post-exertional effects.
- Consideration of disease severity and cardiometabolic health, including obesity and type 2 diabetes, is important.
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