Cardiovascular Aging: From Molecular Mechanisms to Targeted Therapies

Senolytic drugs like dasatinib and quercetin may reduce age-related cardiovascular dysfunction.

• Cardiovascular aging involves complex cellular and molecular changes that affect heart and vascular function.
• Recent advances in pharmacology, gene therapy, and regenerative medicine could help mitigate age-related cardiovascular decline.
• Pharmacological interventions such as rapamycin and metformin may enhance cardiac longevity through metabolic regulation.
• Gene therapies, including CRISPR-based methods, show potential for cardiac regeneration in preclinical models.
• Lifestyle changes, particularly adherence to a Mediterranean diet and regular exercise, are associated with improved vascular health in older adults.
• Challenges exist in drug delivery, patient-specific responses, and the long-term safety of new therapies.

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