Old and New Roles and Evolving Complexities of Cardiovascular Clocks.

Jun 29, 2019The Yale journal of biology and medicine

New and Changing Roles of the Heart's Internal Clocks

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Abstract

Circadian rhythm components significantly influence cardiovascular function and pathology.

  • Circadian rhythms affect thrombosis and blood pressure through oscillations in circulation.
  • Key cardiovascular tissues, including arteries, heart, and kidney, demonstrate molecular oscillations related to circadian rhythm.
  • Mutations in core clock signals may lead to both protective and pathological outcomes in cardiovascular health.
  • Ongoing research highlights the complexity of circadian clock mechanisms in cardiovascular disease.

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