The Yale journal of biology and medicineJun 29, 2019

New and Changing Roles of the Heart's Internal Clocks

Circadian Biology Weekly Brief ↗PubMed ↗

Updated Mar 30, 2026

Abstract

Circadian rhythm components significantly influence cardiovascular function and pathology.

Circadian rhythms affect thrombosis and blood pressure through oscillations in circulation.
Key cardiovascular tissues, including arteries, heart, and kidney, demonstrate molecular oscillations related to circadian rhythm.
Mutations in core clock signals may lead to both protective and pathological outcomes in cardiovascular health.
Ongoing research highlights the complexity of circadian clock mechanisms in cardiovascular disease.

Simplified

The cardiovascular (CV) system has been established to be significantly influenced by the molecular components of circadian rhythm. Oscillations of circadian rhythm occur within the circulation to affect thrombosis and blood pressure and within CV tissues including arteries, heart, and kidney to control function. Physiologic and molecular oscillations of circadian rhythm have been well connected via global, tissue-specific, and transgenic reporter mouse models of key core clock signals such as,, andwhich can produce both pathology and protection with their mutation. With different nuances of CV clock action continuing to emerge in studies of the cardiovascular system, new questions are raised in both new and old mouse model system observations that underscore the importance, complexity, and continued study of the circadian clock mechanism in cardiovascular disease. Bmal1Period Clock,

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New and Changing Roles of the Heart's Internal Clocks

Abstract

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