Nutrition, metabolism, and cardiovascular diseases : NMCD

Heart problems and irregular heartbeat in patients using glucagon-like peptide-1 receptor agonists: Updated analysis of clinical trials

Updated

Abstract

A significant reduction in major cardiovascular events (MACE) was observed with glucagon-like peptide 1 receptor agonists (GLP1-RA), with an odds ratio of 0.87.

  • GLP1-RA is associated with a reduction in all-cause mortality, with an odds ratio of 0.89.
  • There is a non-statistical trend toward reduced heart failure risk, indicated by an odds ratio of 0.93.
  • No increase in the risk of atrial fibrillation was observed, with an odds ratio of 0.94.
  • The analysis included 43 trials with a total of 63,134 patients, all having a duration of at least 52 weeks.

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Funding

Competing interests

Declaration of Competing Interest BN is presently employee of Novo Nordisk; ID has received speaking fees from Novonordisk; FT has no conflicts of interest to declare; EM has received consultancy fees from Merck and Novartis speaking fees from Astra Zeneca, Bristol Myers Squibb, Boehringer-Ingelheim, Eli-Lilly, Merck, Novo Nordisk, Sanofi, and Novartis and research grants from Merck, Novartis, and Takeda. GS has received speaking fees from Novo Nordisk, Merck Sharp & Dohme, Sanofi, Boehringer Ingelheim, Eli Lilly, Astra Zeneca, L-Nutra, Theras, Sanofi, Mundipharma, Omikron, and Novartis, and consultancy fees from Servier, Novo Nordisk, Boehringer Ingelheim, Eli Lilly, Astra Zeneca, Merck Sharp & Dohme, Sanofi, Amgem and GlaxoSmithKline; MM has received speaking fees from Astra Zeneca, Bristol Myers Squibb, Boehringer-Ingelheim, Eli-Lilly, Merck, Novo Nordisk, Sanofi, and Novartis and research grants from Bristol Myers Squibb. All the authors approved the final version of this manuscript. Dr. Matteo Monami is the person who takes full responsibility for the work as a whole, including the study design, access to data, and the decision to submit and publish the manuscript.
PubMed

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