The Cardiovascular Outcomes Between Liraglutide and Dulaglutide Among Different Chronic Kidney Disease Stages in Patients With Type 2 Diabetes

Dec 17, 2024Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Heart health outcomes of Liraglutide versus Dulaglutide in type 2 diabetes patients across chronic kidney disease stages

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Abstract

In a study of 1,572 patients with type 2 diabetes and chronic kidney disease, no significant difference in major adverse cardiovascular events was found between liraglutide and dulaglutide.

Liraglutide users showed an increased incidence of major adverse cardiovascular events with worsening kidney function.
The hazard ratio for MACE in liraglutide users increased from 1.401 at eGFR 60-89 ml/min/1.73 m² to 4.078 at eGFR <15 ml/min/1.73 m².
No similar trend in MACE incidence was found for dulaglutide users across varying kidney function levels.
The findings suggest that dulaglutide may offer a greater cardiovascular benefit in patients with advanced chronic kidney disease.

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OBJECTIVE: This study aimed to evaluate the effectiveness and safety of 2 glucagon-like peptide-1 receptor agonists (GLP-1 RAs) liraglutide and dulaglutide, in patients with type 2 diabetes mellitus (T2DM) at various stages of chronic kidney disease (CKD). In addition to analyzing Major Adverse Cardiovascular Events (MACE) as the primary outcome, kidney function deterioration, renal disease, and other drug-related safety events, such as urinary tract infections, pancreatitis, amputations, and cancers were measured.

RESEARCH DESIGN AND METHODS: This retrospective analysis included 362 842 T2DM patients from the Chang Gung Research Database between 2011 and 2019, identifying 2830 GLP-1 RAs users. After applying exclusion criteria, 1572 patients (945 on liraglutide, 627 on dulaglutide) were included. The primary outcome was MACE incidence across CKD stages.

RESULTS: Of the included patients, 945 used liraglutide, and 627 used dulaglutide. This study found no significant difference in the incidence of MACE between the 2 drugs across varying kidney function levels. However, in patients using liraglutide, a significant increase in MACE incidence was observed with deteriorating kidney function, from an HR of 1.401 (95% CI 0.663-2.958) at an eGFR of 60-89 ml/min/1.73 mto an HR of 4.078 (95% CI 1.111-14.971, P = .0079) at an eGFR of <15 ml/min/1.73 m, a trend not observed in dulaglutide users (P = .1906). 2 2

CONCLUSION: Both liraglutide and dulaglutide are effective GLP-1 RAs in T2DM patients, but their impact on cardiovascular outcomes varies with CKD stage in liraglutide users. In contrast, this trend was not observed with dulaglutide, suggesting a potentially greater cardiovascular benefit of dulaglutide at more advanced CKD stages.

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The Cardiovascular Outcomes Between Liraglutide and Dulaglutide Among Different Chronic Kidney Disease Stages in Patients With Type 2 Diabetes

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