European journal of clinical pharmacology

Heart safety of psilocybin use in mental health treatment: a review

Updated

Abstract

Psilocybin-assisted interventions are transitioning toward psychiatric implementation with a focus on cardiovascular assessment.

  • Trial participants typically undergo medical selection and receive standardized doses of psilocybin.
  • Intensive monitoring in trials differs from the routine care of many patients.
  • Cardiovascular interpretation is essential for evaluating the safety of psilocybin in broader psychiatric applications.
  • A risk-stratified decision framework is proposed to guide psychiatric use of psilocybin.

Simplified

Full Text

Full text is available at the source.

Funding

Competing interests

Declarations. Ethics approval: Not applicable. This manuscript is a narrative review of previously published literature and did not involve new studies in humans or animals performed by the authors. Declaration of generative AI and AI-assisted technologies in the manuscript preparation process: During preparation of this submission, the authors used OpenAI ChatGPT to assist with language editing and adaptation to journal formatting requirements. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the submitted manuscript. Consent to publish: Not applicable. Consent to participate: Not applicable. Competing interests: Lukasz Szarpak, Michal Pruc, Damian Swieczkowski, Bernard Rybczynski, and Aleksandra Pieta declare no conflicts of interest. Wiesław Jerzy Cubała reports grants from Acadia, Alkermes, Allergan, Angelini, Auspex Pharmaceuticals, Beckley Psytech, BMS, Celon, Cephalon, Compass Pathways, Cortexyme, Ferrier, Forest Laboratories, Gedeon Richter, GH Research, GW Pharmaceuticals, HMNC Brain Health, IntraCellular Therapies, Janssen, KCR, Lilly, Lundbeck, Minerva, MSD, NIH, Neumora, Novartis, Orion, Otsuka, Recognify Life Sciences, Sanofi, and Servier; honoraria from Adamed, Angelini, AstraZeneca, BMS, Celon, GH Research, GSK, Janssen, KRKA, Lekam, Lundbeck, Minerva, NeuroCog, Novartis, Orion, Pfizer, Polfa Tarchomin, Sanofi, Servier, and Zentiva; and advisory board participation for Angelini, Celon (ended 2021), Douglas Pharmaceuticals, GH Research, Janssen, MSD, Novartis, Polpharma, Sanofi, and Tasman Therapeutics.
PubMed

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free