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Improving Cas12a- and Cas12i-based tools for precise adenine editing in plant DNA
Updated
Abstract
Essence
Coupling high-activity Cas12 nucleases with dimeric TadA-8e is presented as a way to improve plant adenine base editing.
Evidence
A plant-genome editor optimization study used Cas12a- and Cas12i-based adenine base editors built from high-activity nucleases and dimeric TadA-8e.
Caveat
Because the abstract gives no plant species, loci, editing rates, or off-target results, the scope and precision of the improvement are hard to judge.
Simplified
CRISPR Gene Editing