Journal of translational medicine

CD73-coated nanoparticles boost anti-cancer T-cell response by enhancing immune-activating dendritic cells through TLR3

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Abstract

The evaluation of a CD73 mRNA vaccine shows potential for antitumor immune effects in murine models.

  • Current mRNA vaccines face challenges due to limited immune response to target antigens.
  • The CD73 protein has been identified as a target for enhancing immunogenicity.
  • Understanding how the CD73 mRNA vaccine works could improve its application in cancer immunotherapy.

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Funding

Competing interests

0 of 10
authors report competing interests
10 report none
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The authors declare no competing interests.

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