A low-dose self-amplifying mRNA vaccine targeting HPV16 E6/E7 triggers strong T-cell immunity and tumor protection in mice

Declarations. Conflict of interest: The authors declare no conflict of interests. Ethical approval and consent to participate: All animal experiments involving mice were conducted in strict accordance with the Animal Ethics Procedures and Guidelines of the People’s Republic of China. The experimental protocols were reviewed and approved by the Animal Care and Use Committee of Hangzhou Medical College. Consent for publication: This manuscript has not been published or presented elsewhere in part or in entirety, and is not under consideration by another journal. All the authors have approved the manuscript and agree with submission to your esteemed journal.