Trends in neurosciences

Independence and Coordination of Internal Clocks in the Brain's Daily Rhythm Center

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The suprachiasmatic nucleus (SCN) operates as the master circadian pacemaker in mammals.

  • Individual cells within the SCN can function independently yet must connect to form a unified circadian network.
  • The SCN's network properties enable coordination of circadian rhythms among its neurons and subpopulations.
  • There is growing evidence for the existence of multiple interconnected oscillators within the SCN.
  • Recent advances shed light on the complex organization and function of the SCN's cellular and network-level clock.
  • Understanding how synchronization occurs between SCN cells may reveal the mechanisms behind circadian rhythm orchestration in mammals.

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