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Calcium Circadian Rhythmicity in the Suprachiasmatic Nucleus: Cell Autonomy and Network Modulation
Daily Calcium Rhythms in the Brain's Internal Clock: Independent Cell Patterns and Network Influence
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Abstract
of intracellular calcium levels in SCN neurons may be driven by circadian clock gene expression.
- Circadian clock gene expression and intracellular calcium levels exhibit autonomous circadian rhythms in SCN neurons.
- Intracellular calcium rhythms are typically weaker than the rhythms of clock gene expression in dispersed SCN cells.
- In SCN slice cultures, both clock gene and calcium rhythms are stronger compared to dispersed cells.
- Blocking neuronal firing in slice cultures weakens calcium rhythms but does not affect rhythms in dispersed cells.
- The phase relationship between calcium levels and clock gene rhythms varies more in slice cultures than in dispersed cells.
- Both calcium and clock gene rhythms are abolished in SCN cells lacking the essential clock gene.
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Key numbers
80 of 100
Cellular Rhythmicity
Percentage of cells with significant rhythms in dispersed cultures.
40 of 100
Calcium Rhythmicity
Percentage of cells with significant [Ca] rhythms in dispersed cultures.
71%
Increased Rhythmicity in Slices
Percentage of cells with rhythmic [Ca] in SCN slice cultures.